Dr.Afra Hadjizadeh

      Nature-inspired & Biomimetic Nanobiomaterials

    for Tissue Engineering (NBNTE)

What we have already done

  • Bioinspired nanomaterials

    "Bioinspired nanomaterials"
  • Bioinspired nanomaterials

    "Bioinspired nanomaterials"
  • Bioinspired nanomaterials

    "Bioinspired nanomaterials"
  • Electrospun natural scaffolding materials

    "Electrospun natural scaffolding materials"
  • Electrospun natural scaffolding materials

    "Electrospun natural scaffolding materials;
  • Electrosun Beaded fibers -biodegradable polymer

    "Electrosun Beaded fibers -biodegradable polymer"
  • Electrosun micro fibers -biodegradable polymer

    "Electrosun micro fibers -biodegradable polymer"
  • Tissue engineering-angiogenesis-phase contrast mic

    "Tissue engineering - angiogenesis- phase contrast mic"
  • Tissue engineering-angiogenesis-phase contrast mic

    "Tissue engineering - angiogenesis-confocal mic"
  • Tissue engineering-angiogenesis-flouresence mic

    "Tissue engineering - angiogenesis-flouresence mic"
  • Bioactive fiber cell interaction

    "Bioactive fiber cell interaction"
  • Bioinnert fiber-cell interaction

    "Bioinnert fiber-cell interaction"i>
  • Cells on the bioactive fiber- confocal mic

    "Cells on the bioactive fiber- confocal mic1"
  • Cells on the fiber-confocal mic

    "Cells on the fiber- confocal mic"
  • Biodegradable porous hollowmembran scaffold

    "Biodegradable porous hollowmembran scaffold "
  • Biodegradable porous hollowmembran scaffold

    "Biodegradable porous hollowmembran scaffold"
  • Biodegradable porous hollowmembran scaffold

    "Biodegradable porous hollowmembran scaffold"
  • Biodegradable porous hollowmembran scaffold

    "Biodegradable porous hollowmembran scaffold"
  • CMD grafted surface-SEM

    "CMD grafted surface-SEM"
  • Multilayer bioactive surface modification

    "Multilayer bioactive surface modification"
  • Plasma polymer coated surface-AFM

    "Plasma polymer coated surface AFM"
  • Plasma polymer coated surface-AFM

    "Plasma polymer coated surface-AFM"
  • Plasma polymer coated surface-SEM

    "Plasma polymer coated surface-SEM"
  • Sphere attache AFM tip-force measurment

    "Sphere attache AFM tip-force measurment"
  • Vascular tissue engineering

    "Vascular tissue engineering"
  • Vascular tissue engineering

    "Vascular tissue engineering"
  • Vascular tissue engineering

    "Vascular tissue engineering"
  • Vascular tissue engineering

    "Vascular tissue engineering"
  • Vascular tissue engineering

    "Vascular tissue engineering"
  • Vascular tissue engineering

    "Vascular tissue engineering"

Nano/microstructured biomaterials

Vascular tissue engineering

The lack of an appropriate autologous vessel or an artificial substitute in treating severe vascular diseases has gained the attention of researchers towards developing tissue engineered vascular substitutes. In this regard, producing new synthetic scaffolds with suitable physical, mechanical and biological properties to preserve the normal function of a regenerated vascular tissue appears a challenging but promising alternative. PET offers many advantages for being applied for small diameter vascular graft application; including, mechanical properties, biocompatibility and cost-effectiveness. Moreover, its processability into fibrous structures permits suitable structural designs. Electrospun nanofibrous polymeric structures with high porosity, interconnected pores and large surface are valuable material for tissue engineering scaffolds. Their typical nonwoven nanostructure or microstructure supports cell adhesion, proliferation, diffusion of nutrients and waste products (Lee et al., 2007; Wang, 2009). With regard to the aforementioned discussion, we attempted to develop a small diameter vascular graft scaffold composed of nanofibrous and microfibrous electrospun PET mats, by taking advantages from nanoscale and microscale fibers to control vascular cell behavior. Therefore, the specific objective of this study is to evaluate the effect of PET nanofibers on the luminal surface endothelialization in a vascular graft scaffold, compared to that of microfibers.

  

Nerve tissue engineering

Neural stem cells have the potential of self renewal; as well as differentiate into different neural cell types. This offer advantages for NSC based cell therapies to treat neurodegenerative diseases and traumatic injuries. However in order to be able to apply this strategy in clinical applications, appropriate approaches are needed for large scale cell expansion, as well as for controlled cell differentiation to functional cell types for transplantation. With regard to their nanofibrous microenvironment in vivo, with specific physical, biochemical and topographical properties, we should first understand the effect of these cues on NSC functions and then provide similar artificial environment to achieve the above mentioned goal. To this aim we have prepared electrospun PLA mats with various fiber diameters and tested them towards NSC behaviour.